GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs2836974 | 1 | rs12710454 | chr21:40656919 | PSMG1 | chr21:40547390-40555440:- | -0.2 | -6.7 | 3.39E-11 | Cognitive function |
| BRCA | cis | rs2041840 | 1 | rs12712530 | chr2:37505561 | CEBPZ | chr2:37428778-37458740:- | -0.16 | -5.03 | 5.83E-7 | Chronic lymphocytic leukemia |
| BRCA | cis | rs6741892 | 1 | rs12712612 | chr2:38907605 | GALM | chr2:38893052-38961908:+ | 0.37 | 6.43 | 1.87E-10 | 5-HTT brain serotonin transporter levels |
| BRCA | cis | rs7586879 | 1 | rs12713419 | chr2:25121853 | LOC375190 | chr2:24299728-24397519:+ | -0.13 | -3.69 | 0.000239 | Body mass index |
| BRCA | cis | rs13358904 | 1 | rs12719140 | chr5:111602603 | FLJ11235 | chr5:111755280-111756673:+ | 0.13 | 3.84 | 0.000131 | Suicide ideation score in major depressive disorder |
| BRCA | cis | rs12725198 | 1 | rs12725198 | chr1:16080171 | SLC25A34 | chr1:16062809-16067885:+ | 0.13 | 4.13 | 3.84E-5 | Cardiac Troponin-T levels |
| BRCA | cis | rs12080794 | 1 | rs12727982 | chr1:9150789 | SLC2A5 | chr1:9097007-9148510:- | -0.16 | -3.5 | 0.000483 | Response to antidepressant treatment (citalopram) |
| BRCA | cis | rs111803315 | 1 | rs1273153 | chr14:59946459 | C14orf149 | chr14:59939406-59951126:- | 0.27 | 4.83 | 1.56E-6 | Schizophrenia |
| BRCA | cis | rs111803315 | 1 | rs1273153 | chr14:59946459 | JKAMP | chr14:59951161-59972080:+ | -0.17 | -3.55 | 0.000403 | Schizophrenia |
| BRCA | cis | rs11590090 | 1 | rs12732455 | chr1:113310684 | FAM19A3 | chr1:113263189-113269854:+ | 0.21 | 6.46 | 1.56E-10 | Hyperactive-impulsive symptoms |
| BRCA | cis | rs11590090 | 1 | rs12732455 | chr1:113310684 | LRIG2 | chr1:113615831-113667342:+ | -0.11 | -3.42 | 0.000644 | Hyperactive-impulsive symptoms |
| BRCA | cis | rs11590090 | 1 | rs12733192 | chr1:113310418 | FAM19A3 | chr1:113263189-113269854:+ | 0.19 | 6.1 | 1.49E-9 | Hyperactive-impulsive symptoms |
| BRCA | cis | rs11590090 | 1 | rs12733192 | chr1:113310418 | LRIG2 | chr1:113615831-113667342:+ | -0.12 | -4.09 | 4.71E-5 | Hyperactive-impulsive symptoms |
| BRCA | cis | rs17401966 | 1 | rs12734068 | chr1:10376803 | PGD | chr1:10459085-10480200:+ | 0.22 | 6.19 | 8.81E-10 | Hepatocellular carcinoma |
| BRCA | cis | rs17401966 | 1 | rs12734551 | chr1:10391536 | PGD | chr1:10459085-10480200:+ | 0.21 | 6 | 2.71E-9 | Hepatocellular carcinoma |